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This functional refractoriness to growth hormone is also seen in starvation and may be due to insufficient portal vein insulin for normal hepatic IGF-I synthesis.
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In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection.
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Similarly, in 378 subjects with type 1 diabetes who received once-daily insulin glargine and prandial insulin lispro, the 24-hour glucose profiles were identical, regardless of whether the basal insulin was injected at breakfast, dinner, or bedtime.
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The reader is referred to the volume edited by Cohen, Kessler and Underwood Gordon (1995) for detailed descriptions of measurement issues and measures for each of these approaches.
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Surprisingly, the bulk of the interaction with the receptor leucine-rich repeat ligand-binding domain is indirect and mediated through a helical peptide segment ( αCT) that is provided by the alternate insulin partner in the receptor dimer.
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